Penn State Cancer Institute has joined forces with the nationwide Big Ten Cancer Research Consortium (BTCRC), an organization that pools resources from 12 major educational institutions. Without the bureaucracy typically associated with larger cooperative groups, the BTCRC strives to advance the fight against cancer with greater speed and agility.
This is evidenced in the ability of members to share their resources for clinical trial research, benefiting patients of member institutions by allowing them to gain access to clinical trials being conducted throughout the Consortium. The BTCRC was first established in 2011, and all current members, including Penn State Cancer Institute, were members by 2013. It arose as a result of the diminishing research opportunities for junior faculty and greater demands to pre-screen large populations to identify small, molecularly-enriched subsets.1 “Our membership in BTCRC allows access to new research ideas, often proposed by more junior investigators, in front of a national audience far more quickly than would otherwise be possible,” says Raymond Hohl, MD, PhD, director, Penn State Cancer Institute. Continue reading “Big Ten Cancer Research Consortium: Leveraging Scientific and Clinical Expertise in the Fight Against Cancer”→
Penn State Cancer Institute has established a novel mode of breast carcinogenesis by discovering how communication between genetically distinct subclones contributes to tumor growth in Wnt-driven mammary cancers, a widely used murine breast cancer model.1 Although subsequent studies also have described cooperative interactions between certain tumor cell subpopulations, suggesting subclonal cooperation may be a common mechanism for the maintenance of tumor cell heterogeneity, this study, published in Nature, was the first to recognize the possible relationship. “As cancer biologists and clinicians have long known, cancers evolve,” says Edward J. Gunther, MD, professor of medicine, Penn State Cancer Institute. “But this idea that there are multiple subclones evolving in concert is new. Eventually, this broadened understanding will lead to a further evolution of cancer treatment strategies.” Continue reading “Groundbreaking Research Demonstrates New Mode of Carcinogenesis Hope for Far Less Toxic Treatment”→